Neurons rely on complex molecular mechanisms to communicate with each other through the release of neurotransmitters. The second edition of “Molecular Mechanisms of Neurotransmitter Release” provides a comprehensive exploration of the intricate processes involved in neurotransmitter release. This book covers a wide range of topics, from the molecular architecture and cytomatrix proteins at presynaptic sites to the different modes of synaptic vesicle exocytosis, including full-collapse and kiss-and-run mechanisms.
The book delves into key molecules responsible for synaptic vesicle fusion, such as SNARE proteins, as well as the molecules that closely interact with them, including UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins. It also examines the calcium sensors involved in synaptic vesicle fusion, such as synaptotagmins and Doc2s, and explores the sources of calcium that trigger synaptic exocytosis, such as voltage-gated calcium channels and ryanodine receptors.
In addition, the book covers the regulation of neurotransmitter release by various factors, including potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To ensure clarity and understanding, the book provides background information and features numerous illustrations and diagrams.
The second edition includes major updates to existing chapters and introduces new chapters to reflect recent advancements in the field. “Molecular Mechanisms of Neurotransmitter Release, 2nd edition” is a valuable resource for neuroscience students and serves as a reference for neuroscientists, offering a comprehensive and up-to-date exploration of the molecular processes underpinning neurotransmitter release.
